Football is back.
The 2025 NFL season will officially begin with the annual Hall of Fame Game on Thursday, July 31, when the Los Angeles Chargers take on the Detroit Lions at Tom Benson Hall of Fame Stadium in Canton, Ohio. Although it’s technically preseason, there’s still plenty to watch and bet on.
Let’s analyze the odds, storylines, and predictions for this opening matchup.
Hall of Fame Game Odds and Betting Line
- Spread: Lions -1.5
- Total: 32.5 points
- Moneyline: Lions -135, Chargers +115
Oddsmakers are giving the Lions a slight edge, but that line could be misleading, given the way both teams are approaching this game.
Chargers focus on evaluating Trey Lance
The Chargers plan to take a detailed look at Trey Lance, as the 2021 No. 3 overall pick is expected to play until the third quarter. This is a significant opportunity for Lance, who is competing for the backup role behind Justin Herbert.
The Bolts also have skilled new players like Trey Harris, KeAndre Lambert-Smith and Omarion Hampton who are expected to get a chance to perform well. Expect a motivated team—especially under head coach Jim Harbaugh, who historically leans toward playing with intensity in the preseason.
The Lions are taking a conservative approach
The Lions have made it clear: the starters will play with comfort. Detroit will rely on Hendon Hooker and veteran Kyle Allen at quarterback, both of whom will try to cement their spots on the depth chart.
A transition factor is also at play. Both of Detroit’s respected coordinators—Ben Johnson (offense) and Aaron Glenn (defense)—left in the offseason, meaning this game could serve more as a feel-out exercise under new systems.
Betting Trends and Predictions: Chargers vs Lions
- The last three Hall of Fame contests have been won by underdogs
- The last three games have gone to the Over (average 37+ points)
- Home teams (nominees) are 4-0 in recent editions
Pick: Chargers ML (+115)
Trey Lance has a lot more to prove, and the Chargers are fielding a more competitive team that will be a great trial for some really deep players. Detroit’s more passive approach and coaching turnover are tipping the scales in Los Angeles’ favor.
Bonus Lean: Over 32.5 (-110)
Despite historically trending toward the Under, recent Hall of Fame contests have been dominated by the Over. With two dynamic backup quarterbacks and potential defensive mistakes, there’s room to rack up points here.
Final Score Prediction: Chargers 20, Lions 17
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